- "Wish you were a part of it? You could have been a nonconformist just like the rest of us!"
- ―Casandra, Pico's School
Casandra (also spelt Cassandra) is the main antagonist and final boss of Pico's School. She is fought at the very end of the game and is found in the Teacher's Lounge.
Casandra has short red hair with two points at the front, comparable to demon horns, white eyes and a red bandana. She wears a grey jacket and boots with red soles and bright yellow upside down crosses. She also has short red nails, wears red lipstick on her bottom lip and carries a gun in her right hand and a small dark gray book in her left with a yellow pentagram on it.
- At the beginning of the game Casandra shouts "KEIN MEHRHEIT FÜR DIE MITLEID," German for "no pity for the majority," a reference to the German industrial band KMFDM.
- This is a reference to Eric Harris, one of the Columbine school shooters, who posted lyrics of KMFDM's Stray Bullet on his personal website.
- The band's political stance may have influenced Casandra, as themes of anti-fascism are present. Ironically, there's a lot more songs by them that are anti-war and anti-violence.
- In the German translation:
- Casandra's name is spelt Cassandra.
- their German message is changed to "KEIN MITLEID MEHR" instead, which roughly translates to "no more pity."
- She instead says that the German education system is "bullshit" rather than American.
- According to Cyclops, Casandra has a crush on Pico, which is why he isn't dead at the start of the game.
- Casandra is likely based off of Aaron Cole, a fan of Tom Fulp, who emailed him during the aftermath of the Columbine School Massacre.
- The influence can be seen with her speaking German and identifying with gothic culture.
- If you shoot the flammable barrel during the final fight with Casandra, it will explode, causing the wall behind her to collapse. After that, the police will help you fight Casandra, which awards you with the "Bruckheimer" achievement.
- The form that Casandra takes near the end if the game is an alien; this is shown in Samurai Asshole, where two can seen talking to each other after the titular Samurai gets on the rocket.
- Casandra’s gender was never explicitly stated in the original series; the same goes for Hanzou.
- Fans speculate that Casandra is transgender, due to her final monster form presenting as male.